top of page
Stack of Magazines


COFFI publications

  • Verveen, A., Müller, F., Lloyd, A., Moss-Morris, R., Omland, T., Penninx, B., Raijmakers, R. P. H., van der Schaaf, M., Sandler, C. X., Stavem, K., Wessely, S., Wyller, V. B. B., Nieuwkerk, P., & Knoop, H. (2022). A research agenda for post-COVID-19 fatigue. Journal of Psychosomatic Research, 154, 110726.

  • Sandler, C. X., Wyller, V. B. B., Moss-Morris, R., Buchwald, D., Crawley, E., Hautvast, J., Katz, B. Z., Knoop, H., Little, P., Taylor, R., Wensaas, K. A., & Lloyd, A. R. (2021). Long COVID and post-infective fatigue syndrome: A review. In Open Forum Infectious Diseases (Vol. 8, Issue 10). Open Forum Infect Dis.

  • Katz B, Collin SM, Murphy G, Moss-Morris R, Wyller VB, Wensaas K-A, Hautvast JLA, Bleeker-Rovers CP, Vollmer-Conna U, Buchwald D, Taylor R, Little P, Crawley E, White PD, Lloyd, A. The international collaborative on fatigue following infection (COFFI). Fatigue 2018; 6: 106-21.

CEBA publications


  • Asprusten, T. T., Pedersen, M., Skovlund, E., & Wyller, V. B. (2019). EBV-requisitioning physicians’ guess on fatigue state 6 months after acute EBV infection. BMJ Paediatrics Open, 3(1), 46–59.

  • Pedersen, M., Asprusten, T. T., Godang, K., Leegaard, T. M., Osnes, L. T., Skovlund, E., … Wyller, V. B. B. (2019). Lifestyle factors during acute Epstein–Barr virus infection in adolescents predict physical activity six months later. Acta Paediatrica, International Journal of Paediatrics, 108(8), 1521–1526.

  • Kristiansen, M. S., Stabursvik, J., O’Leary, E. C., Pedersen, M., Asprusten, T. T., Leegaard, T., … Wyller, V. B. B. (2019). Clinical symptoms and markers of disease mechanisms in adolescent chronic fatigue following Epstein-Barr virus infection: An exploratory cross-sectional study. Brain, Behavior, and Immunity, 80, 551–563.

  • Pedersen, M., Asprusten, T. T., Godang, K., Leegaard, T. M., Osnes, L. T., Skovlund, E., … Wyller, V. B. B. (2019). Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study

  • Pedersen, M., Asprusten, T. T., Godang, K., Leegaard, T. M., Osnes, L. T., Skovlund, E., … Wyller, V. B. B. (2019). Fatigue in Epstein-Barr virus infected adolescents and healthy controls: A prospective multifactorial association study. Journal of Psychosomatic Research, 121, 46–59.

  • Wyller, V. B. B. (2019). Autonomic and inflammatory disturbances do not seem to explain symptoms in chronic fatigue. Brain, Behavior, and Immunity, 80, 901.

  • Malik, S., Asprusten, T. T., Pedersen, M., Mangersnes, J., Trondalen, G., Van Roy, B., … Wyller, V. B. (2020). Cognitive-behavioural therapy combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: A feasibility study. BMJ Paediatrics Open, 4(1).

DIOS publications

  • Bennett  BK,  Hickie  IB,  Vollmer-Conna  US,  et  al.  The  relationship  between  fatigue, psychological  and   immunological  variables   in  acute   infectious   illness.   Aust   NZ   J Psychiatry. 1998; 32: 180-6.

  • Harris RJ, Storm PA, Lloyd A, Arens M. Marmion BP. Long term persistence of Coxiella burnetii in the host after primary Q fever. Epidemiol & Infection 2000; 124:543-9.

  • Robertson P, Beynon S, Whybin R, et al. Measurement of EBV-IgG anti-VCA avidity aids the early and reliable diagnosis of primary EBV infection. J Med Virol. 2003; 70: 617-23.

  • Vollmer-Conna  U,  Fazou  C,  Cameron  B,  Li  H,  Brennan  C,  Luck  L,  Davenport  T, Wakefield D, Hickie I, Lloyd A. Production of pro-inflammatory cytokines correlates with the symptoms of acute sickness behaviour in humans. Psychol Med 2004; 34: 1289-97.

  • Helbig  K,  Harris  R,  Ayres  J,  Dunckley  H,  Lloyd  AR,  Robson  J,  Marmion  BP.  Immune response genes in the   post-Q-fever fatigue syndrome, Q fever endocarditis and uncomplicated acute primary Q fever. QJ Med 2005; 98: 565–74. 

  • Vernon  SD,  Whistler  T,  Cameron  B,  Hickie  IB,  Reeves  WC,  Lloyd  AR.  Preliminary evidence   of   mitochondrial   dysfunction   associated   with   post-infective   fatigue   after infection with Epstein-Barr virus. BMC Infectious Diseases 2006,

  • Vernon  SD,  Nicholson  A,  Rajeevan  M,  Dimelescu  I,  Cameron  B,  Whistler  T,  Lloyd  Correlation  of psych-neuroendocrine-immune  (PNI) gene  expression  with  symptoms of acute infectious mononucleosis. Brain Research 2006; 1068: 1-6.

  • Cameron  B,  Bharadwaj  M,  Burrows  J,  Fazou  C,  Wakefield  D,  Hickie  I,  Ffrench  R, Khanna  R,  Lloyd  A for the  Dubbo  Infection  Outcomes Study Group.  Prolonged  illness after   infectious   mononucleosis   is   associated   with   altered   immunity,   but   not   with increased viral load. J Infectious Dis 2006; 193: 664-71.

  • Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC,  Lloyd AR,  for  the  Dubbo  Infection  Outcomes  Study  Group.  Post-infective  and chronic  fatigue  syndromes  precipitated  by  viral  and  non-viral  pathogens:  prospective cohort study. BMJ 2006; 333; 575-80.

  • Cameron B, Galbraith S, Zhang Y, Davenport T, Vollmer-Conna U, Wakefield D, Hickie I, Dunsmuir W, Whistler T, Vernon S,  Reeves WC,  Lloyd  AR, for the  Dubbo  Infection Outcomes Study Group. Gene expression correlates of post-infective fatigue syndrome after infectious  mononucleosis. J Infectious Dis, 2007; 196: 56-66.

  • Vollmer-Conna U, Cameron B, Hadzi-Pavlovic D, Singletary K, Davenport T, Nisenbaum R,  Vernon S,  Reeves  WC,  Hickie  I,  Wakefield  D,  Lloyd  AR,  for  the  Dubbo  Infection Outcomes Study Group. Post-infective fatigue syndrome  is not associated  with altered cytokine production. Clinical Infectious Diseases. 2007 45; 732-5.

  • Everett  B,  Cameron  B,  Li  H,  Vollmer-Conna  U,  Davenport  T,  Hickie  I,  Wakefield  D, Vernon S, Reeves WC, Lloyd AR. Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever. Genes and Immunity, 2007; 8: 699-702. doi: 10.1038/sj.gene.6364428

  • Vollmer-Conna U, Piraino B, Cameron B, Davenport T, Hickie  I, Wakefield D, Lloyd A. Cytokine polymorphisms  have  a  synergistic  effect  on  severity  of  the  acute  sickness response to infection. Clinical Infectious Diseases 2008; 47: 1418-25.

  • Hickie I, Davenport T, Vernon SD, Nisenbaum R, Reeves WC, Hadzi-Pavlovic D, Lloyd AR  and  the  International Chronic  Fatigue  Syndrome  Study Group.  Are  chronic fatigue and  chronic  fatigue  syndrome  valid  clinical  entities  across  countries  and  health-care zealand Journal of Psychiatry 2009,43:25-35.

  • Kadota Y, Cooper G, Burton AR, Lemon J, Schall U, Lloyd A, Vollmer-Conna U. Autonomic hyper-vigilance in post-infective fatigue syndrome. Biol Psychol 2010; 85: 97-103.

  • Cameron B, Hirschberg DL, Rosenberg-Hassan Y, Ablashi D, Lloyd AR. Serum cytokine levels in postinfective fatigue syndrome. Clinical Infectious Diseases 2010,50:278-279.

  • Cameron  B,  Flamand  L,  Juwana  H,  Middeldorp  J,  Naing  Z,  Rawlinson  W,  et  al. Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6  in post-infective  fatigue  syndrome.  Journal  of  Medical  Virology  2010,82:1684- 1688.

  • Galbraith S, Cameron B, Li H, Lau D, Vollmer-Conna U, Lloyd AR. Peripheral blood gene expression  in  postinfective  fatigue  syndrome  following  from  three  different  triggering infections. Journal of Infectious Diseases 2011,204:1632-1640.

  • Piraino B, Vollmer-Conna U, Lloyd A. Genetic associations of fatigue and other symptom domains of the acute sickness response to infection. Brain Behav Imm 2012, 26:552- 558. Gunaratne P, Lloyd AR, Vollmer-Conna U. Mood disturbance after infection. Australian & New Zealand Journal of Psychiatry 2013, 47:1152-1164.

  • Cvejic E, Lemon J, Hickie IB, Lloyd AR, Vollmer-Conna U. Neurocognitive disturbances associated with acute infectious mononucleosis, Ross River fever and Q fever: a preliminary investigation of inflammatory and genetic correlates. Brain Behav Imm 2014, 36:207-214.

  • Bennett BK, Goldstein D, Chen M, Davenport TA, Vollmer-Conna U, Scott EM, Hickie IB, Lloyd AR. Characterization of fatigue states in medicine and psychiatry by structured interview. Psychosom Medicine 2014, 76:379-388.

  • Cvejic, E., Li, H., Hickie, I. B., Wakefield, D., Lloyd, A. R., & Vollmer-Conna, U. (2019). Contribution of individual psychological and psychosocial factors to symptom severity and time-to-recovery after naturally-occurring acute infective illness: The Dubbo Infection Outcomes Study (DIOS). Brain, Behavior, and Immunity, 82(1), 76–83.

Dutch Q fever study (IMPAQT)

  • Van Loenhout JA, Hautvast JL, Vercoulen JH, Akkermans RP, Wijkmans CJ, van der Velden K, Paget WJ. Q-fever patients suffer from impaired health status long after the acute phase of the illness: results from a 24-month cohort study. J Infect. 2015 Mar;70(3):237-46. doi: 10.1016/j.jinf.2014.10.010.

  • van Loenhout JA, Hautvast JL, Akkermans RP, et al. Work participation in Q-fever patients and patients with Legionnaires’ disease: a 12-month cohort study. Scand J Public Health 2015; 43: 294–301.


LoTECA publications

  • Selvakumar J, Havdal LB, Drevvatne M, Brodwall EM, Lund Berven L, Stiansen-Sonerud T, Einvik G, Leegaard TM, Tjade T, Michelsen AE, Mollnes TE, Lund-Johansen F, Holmøy T, Zetterberg H, Blennow K, Sandler CX, Cvejic E, Lloyd AR, Wyller VBB. Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults. JAMA Netw Open. 2023 Mar 1;6(3):e235763. Doi: 10.1001/jamanetworkopen.2023.5763. PMID: 36995712; PMCID: PMC10064252.

  • Sommen SL, Havdal LB, Selvakumar J, Einvik G, Leegaard TM, Lund-Johansen F, Michelsen AE, Mollnes TE, Stiansen-Sonerud T, Tjade T, Wyller VBB, Berven LL. Inflammatory markers and pulmonary function in adolescents and young adults 6 months after mild COVID-19. Front Immunol. 2023 Jan 6;13:1081718. doi: 10.3389/fimmu.2022.1081718. eCollection 2022.PMID: 36685555.

  • Havdal LB, Berven LL, Selvakumar J, Stiansen-Sonerud T, Leegaard TM, Tjade T, Zetterberg H, Blennow K, Wyller VBB. Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults. Front Neurol. 2022 Jun 22;13:915712. doi: 10.3389/fneur.2022.915712. eCollection 2022.PMID: 35812102

  • Lund Berven L, Selvakumar J, Havdal L, Stiansen-Sonerud T, Einvik G, Leegaard TM, Tjade T, Michelsen AE, Mollnes TE, Wyller VBB. Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults. Front Immunol. 2022 Feb 9;13:837288. doi: 10.3389/fimmu.2022.837288. eCollection 2022.PMID: 35222429

PHOSP-COVID publications

  • Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB, Lone NI, Leavy OC, Daines L, Baillie JK, Brown JS, Chalder T, De Soyza A, Diar Bakerly N, Easom N, Geddes JR, Greening NJ, Hart N, Heaney LG, Heller S, Howard L, Hurst JR, Jacob J, Jenkins RG, Jolley C, Kerr S, Kon OM, Lewis K, Lord JM, McCann GP, Neubauer S, Openshaw PJM, Parekh D, Pfeffer P, Rahman NM, Raman B, Richardson M, Rowland M, Semple MG, Shah AM, Singh SJ, Sheikh A, Thomas D, Toshner M, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Wain LV, Brightling CE; PHOSP-COVID Collaborative Group. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. Lancet Respir Med. 2021 Nov;9(11):1275-1287. doi: 10.1016/S2213-2600(21)00383-0. PMID: 34627560. 

  • The PHOSP-COVID Collaborative Group. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. Lancet Respir Med. 2022 Aug;10(8):761-775. doi: 10.1016/S2213-2600(22)00127-8. Epub 2022 Apr 23 

Prospective Study CFS following IM 

  • Katz BZ, Stewart JM, Shiraishi Y, Mears CJ, Taylor R. Autonomic symptoms at baseline and following infectious mononucleosis in a prospective cohort of adolescents. Arch Pediatr Adolesc Med. 2011;165(8):765-766. doi:10.1001/archpediatrics.2011.124

  • Katz BZ, Boas S, Shiraishi Y, Mears CJ, Taylor R.  Exercise tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.  J Pediatr 2010; 157:468-72.  Doi:10.1016/j.peds.2010.03.025.  PMID: 20447647

  • Huang Y, Katz BZ, Mears C, Kielhofner GW, Taylor R.  Post-infectious fatigue in adolescents and physical activity.  Arch Pediatr Adol Med 2010;164:803-9.  PMID: 20819961

  • Taylor R, O’Brien J, Kielhofner GW, Lee S-W, Katz BZ, Mears CJ.  The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.  Brit J Occ Therapy 2010; 73:524-30.

  • Katz BZ, Stewart J, Shiraishi Y, Mears CJ, Taylor R.  Orthostatic tolerance  testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.  Clin Pediatr 2012; 51(9):831-5.  DOI 10.1177/0009922812455094.     PMID: 22850676

  • Broderick G, Katz BZ, Fletcher MA, Klimas N, Smith FA, O’Gorman MRG, Vernon SD, Taylor R.  Cytokine expression profiles characteristic of immune imbalance in post-mononucleosis chronic fatigue.  J Translational Med 2012; 10:191.  Doi: 10.1186/1479-5876-10-191.  PMID: 22973830

  • Katz BZ, Zimmerman D, O’Gorman MRG, Mears CJ, Shiraishi Y, Taylor R.  No evidence for salivary cortisol or natural killer cell dysfunction in adolescents with chronic fatigue syndrome and recovered controls 6, 12 and 24 months following infectious mononucleosis.  Arch Pediatr Inf Dis 2013; 1(5):211-6.  Doi: 10.5812/pedinfect.1310

  • Jason LA, Katz BZ, Shiraishi Y, Mears CJ, Im Y, Taylor R.  Predictors of post-infectious chronic fatigue syndrome in adolescents.  Health Psychology and Behavioral Medicine 2014; 2(1):41-51.  PMID: 24660169.

Prospective Study of the Natural History of IM Caused by EBV

  • Rea TD, Russo JE, Katon W, Ashley RL, Buchwald DS. Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract. 2001 Jul-Aug;14(4):234-42. PMID: 11458965. 

  • Rea TD, Ashley RL, Russo JE, Buchwald DS. A systematic study of Epstein-Barr virus serologic assays following acute infection. Am J Clin Pathol. 2002 Jan;117(1):156-61. doi: 10.1309/ETK2-L9MG-L6RA-N79Y. PMID: 11789721.

  • Wagner HJ, Scott RS, Buchwald D, Sixbey JW. Peripheral blood lymphocytes express recombination-activating genes 1 and 2 during Epstein-Barr virus-induced infectious mononucleosis. J Infect Dis. 2004 Sep 1;190(5):979-84. doi: 10.1086/423211. Epub 2004 Jul 29. PMID: 15295705.

PROTROM publications

  • Stavem K, Ghanima W, Olsen MK, Gilboe HM, Einvik G. Prevalence and Determinants of Fatigue after COVID-19 in Non-Hospitalized Subjects: A Population-Based Study. Int J Environ Res Public Health. 2021 Feb 19;18(4):2030. doi: 10.3390/ijerph18042030. PMID: 33669714; PMCID: PMC7921928.

Qure Study. Treatment of Q-fever fatigue syndrome with CBT vs doxycycline vs placebo

  • Keijmel, S.P., Delsing, C.E., Sprong, T. et al. The Qure study: Q fever fatigue syndrome – response to treatment; a randomized placebo-controlled trial. BMC Infect Dis 13, 157 (2013).

  • Keijmel SP, Delsing CE, Bleijenberg G, van der Meer JWM, Donders RT, Leclercq M, Kampschreur LM, van den Berg M, Sprong T, Nabuurs-Franssen MH, Knoop H, Bleeker-Rovers CP. Effectiveness of Long-term Doxycycline Treatment and Cognitive-Behavioral Therapy on Fatigue Severity in Patients with Q Fever Fatigue Syndrome (Qure Study): A Randomized Controlled Trial. Clin Infect Dis. 2017 Apr 15;64(8):998-1005. doi: 10.1093/cid/cix013. PMID: 28329131.

  • Raijmakers RPH, Keijmel SP, Breukers EMC, Bleijenberg G, van der Meer JWM, Bleeker-Rovers CP, Knoop H. Long-term effect of cognitive behavioural therapy and doxycycline treatment for patients with Q fever fatigue syndrome: One-year follow-up of the Qure study. J Psychosom Res. 2019 Jan;116:62-67. doi: 10.1016/j.jpsychores.2018.11.007. Epub 2018 Nov 12. PMID: 30654996.

ReCOVer publications

  • Kuut TA, Müller F, Aldenkamp A, Assmann-Schuilwerve E, Braamse A, Geerlings SE, Gibney KB, Kanaan RAA, Nieuwkerk P, Olde Hartman TC, Pauëlsen D, Prins M, Slieker K, Van Vugt M, Bleeker-Rovers CP, Keijmel SP, Knoop H. A randomised controlled trial testing the efficacy of Fit after COVID, a cognitive behavioural therapy targeting severe post-infectious fatigue following COVID-19 (ReCOVer): study protocol. Trials. 2021 Dec 2;22(1):867. doi: 10.1186/s13063-021-05569-y. PMID: 34857010; PMCID: PMC8637041.

bottom of page